Pluronic F-68 (Poloxamer 188)

Poloxamer 188, also known as Pluronic F-68, is a triblock copolymer composed of polyoxyethylene-polyoxypropylene-polyoxyethylene (PEO-PPO-PEO). Given its gentle physical properties and chemical stability, Poloxamer 188 finds widespread application in various traditional dosage forms, including suppositories, emulsions, tablets, and gels. Moreover, it has the ability to form micelles, thereby enhancing the concentration of poorly soluble drugs. This copolymer not only boosts the solubility of such drugs but also regulates their release rate. Furthermore, it can restrain the efflux of drugs from efflux pumps, thereby promoting the body's absorption of these drugs.