Summary
Tipiralacil, also known as TPI, is a thymidine phosphorylase inhibitor (TPI). Tipiracil is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials.
TAS-102 is an antitumor agent composed of a combination of trifluorothymidine (FTD), a nucleoside that incorporates into DNA and inhibits a variety of genetic functions required for the proliferation of cancer cells, and tipiracil hydrochloride (TPI), an inhibitor of thymidine phosphorylase (which degrades FTD) that maintains an effective blood concentration of FTD. Tipiracil protects trifluridine from being broken down when taken orally.
Seebio also can supply Tipiracil intermediates as below:
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PRODUCT NAME
CAS NO.
USAGE
5-Chloro-6-(chloromethyl)-2,4(1h,3h)-pyrimidinedione
73742-45-7
Tipiracil
3,4-dihydro-2H-pyrrol-5-amine hydrochloride (1:1)
7544-75-4
Tipiracil
6-(Chloromethyl)uracil
18592-13-7
Tipiracil
Properties
- Name: Tipiracil HCl
CAS#: 183204-72-0
Chemical Formula: C9H12Cl2N4O2
Exact Mass: 278.03373
Molecular Weight: 279.12318
Elemental Analysis: C, 38.73; H, 4.33; Cl, 25.40; N, 20.07; O, 11.46
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly