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Application Scenarios of Dextran Derivatives

Time:2023-11-14 Hits:484
Dextran is a promising drug carrier in biomedicine and is dubbed a "biological missile". As a macromolecule composed of multiple glucose units, the molecular weight of dextran can be tailored according to different applications, ranging from 1,000 to tens of millions. By conjugating with various substances, dextran can produce highly potent and low-toxic drugs. Compared to natural production and extraction, synthetic dextran has higher yields, lower costs, and greater stability, making it an inevitable choice for large-scale applications.
In the field of medicine, dextran has a wide range of applications. It is extensively utilized as a hemolytic diluent, anti-shock infusion, and other formulations, with massive consumption. Iron-containing dextran derivatives, especially iron dextran products, can prevent and treat anemia in humans and animals. Among them, 5% iron-containing derivatives are currently considered the best choice for iron deficiency anemia treatment, particularly suitable for iron supplementation in renal dialysis patients.
Dextran derivatives also have diverse functionalities. Firstly, they can serve as modeling agents, such as dextran sodium sulfate (DSS), the gold standard in colitis modeling research. Secondly, their excellent water solubility allows applications in drug delivery, tissue engineering, and more. Additionally, dextran derivatives can form stable glucosamine conjugates to prepare biosensors, drug delivery systems, etc. These properties make dextran derivatives highly promising research and application materials, providing ample opportunities to explore innovative drug delivery and therapeutic approaches.
Seebio's Dextran Derivatives
Field
Chinese name
Molecular weight
Application
Research application
Dextran sodium sulfate (DSS)
A polyanion derivative, it is the gold standard for inducing colitis in animal models.
Iron dextran
Used to treat iron deficiency anemia caused by chronic blood loss, malnutrition, pregnancy, child development, etc.
Dextran-Azide
2kd~2000kd
Used to deliver metal ions to cells or study metal ion transport.
Dextran-diphenylcyclooctyne
2kd~2000kd
A photosensitizer that can induce apoptosis. Used to treat cancer cells or study apoptosis.
Drug Delivery and Tissue Engineering
Dextran polyethylene glycol thiol
2kd~2000kd
Water-soluble, used in drug delivery and tissue engineering.
Dextran-aldehyde
2kd~2000kd
Forms stable glucosamine conjugates used in biosensors, drug delivery, etc.
Dextran-folic acid
2kd~2000kd
Hydrophobic, used in drug delivery and tissue engineering.
Dextran-polyethylene glycol-carboxyl
2kd~2000kd
Used to prepare hydrogels for drug delivery and tissue engineering.
Dextran-polyethylene glycol-maleimide
2kd~2000kd
Used to prepare polymer-drug conjugates, attach molecules to dextran, drug delivery, targeted therapy.
Dextran-polyethylene glycol-amine
2kd~2000kd
Positively charged, interacts with negatively charged molecules like DNA.
Dextran-polyethylene glycol-active ester
2kd~2000kd
Used to attach molecules like biotin to dextran.
Dextran-cRGD cyclic peptide
2kd~2000kd
Binds integrins involved in cell adhesion. Used in drug delivery, studying cell adhesion.
Biotin-Modified Dextran
Conjugated to streptavidin, used in cell labeling, drug delivery, bioimaging.
Fluorescent Labeling and Bioimaging
Dextran-Chlorin E6
2kd~2000kd
Fluorescent dextran for cell labeling and tracking.
Dextran-Tetramethylrhodamine
2kd~2000kd
Fluorescent dextran for cell labeling, tracking, bioimaging.
Dextran-ICG
2kd~2000kd
Fluorescent dextran for tumor imaging and bioimaging.
CY7 labeled dextran
2kd~2000kd
Fluorescent dextran for cell labeling, tracking, bioimaging.
CY5.5 labeled dextran
2kd~2000kd
Fluorescent dextran for cell labeling, tracking, bioimaging.
Dextran-CY5
2kd~2000kd
Fluorescent dextran for cell labeling, tracking, bioimaging.
Dextran-CY3
2kd~2000kd
Fluorescent dextran for cell labeling, tracking, bioimaging.
Dextran-Rhodamine
2kd~2000kd
Fluorescent dextran for cell labeling, tracking, bioimaging.
Dextran-fluorescein (Dextran-FITC)
Fluorescent, used for cell labeling, bioimaging, studying cell permeability.


 
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