3-Maleimidopropionic acid

3-Maleimidopropionic acid, biochemical grade, [7423-55-4], is an aliphatic N-substituted maleimide.

Specification or Purity: 97%
Alias: N-Maleoyl-β-alanine;N-(2-Carboxyethyl)maleimide;2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-propanoic Acid; 3-(2,5-Dioxo- 2,5-dihydro-pyrrol-1-yl)-propionic Acid
Storage temperature: 2-8°C storage, filled with argon
Shipping conditions: ice pack shipping
 
N-Maleyl-beta-alanine (3-maleimidepropionic acid) is an aliphatic N-substituted maleimide. It is one of the components of a stable solution of EC145, a folate-targeted vinca alkaloid conjugate, used in rodent pharmacokinetic studies.
N-Maleyl-beta-alanine (3-maleimidepropionic acid, N-(2-carboxyethyl)maleimide) is an appropriate reagent used in the following studies:

Decreases the biotin binding affinity of Avd(S16C), an avidin with a single point mutation S16C.
As a side-chain reagent, the tryptic peptide is modified, causing a mass shift indicating the presence of a cysteine residue.
Pre-blocking cysteine exposure in Xenopus oocytes was used as an expression system to study cASIC1a receptor conformational changes.
 
It can be used for the following studies:

Acts as a protective agent for keratin fibers during high temperature processes.
Acts as a non-cleavable maleimide group during the synthesis of four-walled molecule umbrella-octameric arginine conjugates.
Synthesis of N -maleyl-β-organotin carboxylate-alanine.
Functionalized gold surfaces interact with cysteine-modified peptides.
Preparation of cross-linked dextran-polyethylene glycol hydrogel matrix.